LB 500 fLumo luminescence & PET detector

Flow Monitor for Chemiluminescence and Gamma Isotopes in High Background Labs

The fLumo Chemiluminescence Detector for HPLC and liquid chromatography systems uses a highly sensitive head-on photon counting detector with low background.

Different cell sizes can be used to adapt for flow rates and signal intensities.

The compatibility of the evaluation electronics to external analysis systems is guaranteed.



Highly Sensitive Luminescence Monitoring

Due to the low-noise head-on PMT designed to face the sample coil in a direct way makes the fLumo an utmost sensitive detector for faintest traces of chemiluminescence signals.

Background-free Gamma and PET Monitoring

The use of specific measuring cells makes the measurement of high activity gamma emitting istopes as easy as can be even in a high background laboratory.

Operation Mode

The system can be used either in a „stand alone mode", or be connected to a PC. The fLumo system is equipped with a flash memory and a 24 MHz CPU. This allows immediate data processing and easy upgrading.

Multiple Outputs

The user has the option of using the analogue output, the TTL signal or the digital output via a USB connector to a PC.

Downstream Control

Two threshold levels can be set in the FLuMo system which activates solenoid valves, also temporally delayed.


Detection Devicelow noise photon counting PMT
Detection Modeluminescence
gamma and PET isotopes
Digital InterfaceMini USB
Analog OutputTTL
0 to 1 V (10 Hz sampling rate)
DimensionsElectronics: 210 x 60 x 120 mm (w x h x d)
Detector: 150 x 350 x 180 mm (w x d x h)
Flow Cells 
Cell TypesAdmixture cells (Z type)
Solid scint. low background gamma/PET cells (MX type)
Cell Volumes10 to 1000 µL




Besides controlling the detector the PC software offers sophisticated functions for radiochromatographic data evaluation

    recording of max. 4 channels incl. 2 non-isotpic ones
    integration of peaks
    half-life correction
    report generation
    export functionality, e.g. ANDI format

The software is 21 CFR part 11 compliant.


The PC software arranges the data properly in an easy-to-comprehend layout and transfers the data to spreadsheet softwares like EXCEL.



fLumo flow monitor can be used - like HERM - in the development, production and especially quality control of Radio-Pharmaceuticals, PET istope labelled tracer substances and Radio isotope labelled substances:


Thonon et al. (2013). Evaluation of an unshielded luminescence flow-through radio-HPLC detector for LC quality control and preparation of PET radiopharmaceuticals. Applied Radiation and Isotopes 73 (2013), 84-89 Read More


Aufort et al. (2011). Synthesis, in vitro screening and in vivo evaluation of cyclic RGD analogs cyclized through oxorhenium and oxotechnetium coordination. European Journal of Medical Chemistry 46 (5), 1779-1788 Read more


Aufort  et al. (2011). Oxorhenium-Mediated Assembly of Noncyclic Selective Integrin Antagonists: A Combinatorial Approach. ChemBioChem 12 (4), 583-592 Read more


Knott et al. (2011). Simplified and automatic one-pot synthesis of 16α-[18F]fluoroestradiol without high-performance liquid chromatography purification.  J Label Compd Radiopharm, 54: 749–753 Read more


Van Dorpe et al. (2011). Desirability function combining metabolic stability and functionality of peptides. J. Peptide Sci. 17 (5), 398-404 Read more


Van Dorpe (2010). Analytical characterization and comparison of the blood–brain barrier permeability of eight opioid peptides. Peptides 31 (7), 1390-1399 Read more


Alshoukr et al. (2009). Novel Neurotensin Analogues for Radioisotope Targeting to Neurotensin Receptor-Positive Tumors. Bioconjugate Chem 20 (8), 1602–1610 Read More


Aufort et al. (2009). Synthesis and biochemical evaluation of a cyclic RGD oxorhenium complex as new ligand of αVβ3 integrin. European Journal of Medicinal Chemistry 44 (9), 3394-3401 Read More


Vergote et al. (2006). Analysis of iodinated peptides by LC-DAD/ESI ion trap mass spectrometry. Journal of Chromatography B 850  (1-2), 213-220 Read More

Format Size
Bioanalytic Instruments - Product Portfolio Brief overview scope of supply Bioanalytic (June 2014) de, en PDF 693.31 KB
HERM LB 500 HPLC detector brochure Revision 00 12/2016 de, en PDF 1.02 MB
Order Information Consumables & QC Test Devices Version Jan. 2017 de, en PDF 153.63 KB
Press & Media
Format Size
2014-03 (NL March 2014) LB 500 HERM High Energy Radio Monitor HPLC HERM & various LB 124 Contamination Monitors - Berthold Technologies Newsletter March 2014 de, en PDF 118.61 KB
2014-05 (May 2014) FlowStar LB 513 & Radio HPLC Detectors Recent applications FlowStar LB 513 & Radio HPLC Detectors - Berthold Technologies Newsletter May 2014 en PDF 133.71 KB
2014-06 (June 2014) HPLC fLumo & Monitoring LB 500 fLumo Luminescence & PET detector & Radiation Protection Equipment - Berthold Technologies Newsletter June 2014 de, en PDF 133.68 KB

News about this product

A new publication is available describing the evaluation and benefits of using the unshielded and low background Radio HPLC detector fLumo LB 500 in quality control and preparation of PET radiopharmaceuticals.

The advantages outlined are

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