Multi Crystal LB 2111 Gamma Counter

A robust workhorse for RIA

The Multi Crystal LB 2111 gamma counter is a compact, robust and easy-to-use instrument for most applications where gamma-emitting isotopes, e.g. 125I or 51Cr, are used.

The instrument can be operated in a stand-alone mode or it can be hooked to a personal computer. The Multi Crystal LB 2111 gamma counter is available as a 12 detector unit. To increase throughput a second detector block may be added resulting in a 24 detector instrument.

Tabs

Features

High Throughput with 12 or 24 detectors

Sample throughput is high as 12 tubes (or even 24 tubes with the extended model) can be measured at a time, i.e. 200 samples can be measured within 17 min with a 1 min counting time per sample.

Detectors

The 12 detectors are made of high-quality NaI well-type crystal providing best measurement geometry for gamma emitters located in the sample tubes. The crystals cover an energy range up to 500 KeV - suitable for the common isotopes, e.g. 125I, 57Co, 59Fe, 51Cr and 99Tc.

Lead Shielding for low crosstalk

A thick lead shielding of 6 mm around each of the detectors, i.e. in total 12 mm of lead between the detectors, efficiently prevents crosstalk between the samples.

Sample Racks

The sample racks facilitate loading of 12 samples at a time in a most convenient way. With multiple racks all samples of a measurement campaign can be prepared in advance.

The sample rack concept has another important advantage: in case a tube is contaminated on the outside the contamination is never carried on to the instrument. The racks themselves can be cleaned and decontaminated.

Specifications
Detection Unit12 x 1.25" well-type NaI crystals with photomultiplier tubes
Shielding6 mm lead shielding surrounding each detector, i.e. 12 mm lead between detectors
Energy Range0 to 500 keV
Isotopes

125I, 57Co, 51Cr, 59Fe, 99Tc

all other isotopes within the energy range

Tube Formats

Ø 14.5 mm with rack

Ø 16 mm without rack

Performance 
Efficiency

75 % for 125I

35 % for 51Cr

Detector Crosstalk0.413 % for 51Cr
Miscellaneous 
Dimensions395 x 235 x 510 mm (w x d x h)
Weight39 kg
OSWin XP, Win Vista, Win 7 (for use with LBIS)
RegulationsCE, UL, CSA

 

Accessories

LBIS immunoassay software

The Windows software for instrument operation and data evaluation supports competitive (RIA) and immunometric (IRMA) assays with superior curve fitting algorithms increasing the reliability of the calculated results especially at the lower concentrations.

It enables worklist download and sample data upload to host computers.

Up to 4 instruments connceted to a single computer can be run with one LBIS software.

Applications

Radio Immunoassays

Free Testosterone RIA: Yilmaz et al. (2011). Endogenous Testosterone, Endothelial Dysfunction, and Cardiovascular Events in Men with Nondialysis Chronic Kidney Disease. Clinical Journal of the American Society of Nephrology 6 (7), 1617-1625 Read more

Aldosterone RIA: Xing et al. (2011): Aldosterone Production in Human Adrenocortical Cells Is Stimulated by High-Density Lipoprotein 2 (HDL2) through Increased Expression of Aldosterone Synthase (CYP11B2). 152 (3) 751-763 Read more

Radioligand Binding Assays

Binding Assay: Garcia-Perez et al. (2011). New Insights into the Mechanisms whereby Low Molecular Weight CCR5 Ligands Inhibit HIV-1 Infection. Journal of  Biological Chemistry 286, 4978-4990 Read more

Unger et al. (2011). Postprandial ghrelin response is reduced in patients with Parkinson’s disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson’s disease? J Neurol 258, 982-990 Read more

Habibi et al. (2011). Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression. Am J Physiol Heart Circ Physiol 300 (4), 1484-1491 Read more

Parekh et al. (2010). Lifestyle, Anthropometric, and Obesity-Related Physiologic Determinants of Insulin-like Growth Factor-1 in the Third National Health and Nutrition Examination Survey (1988–1994). Annals of Epidemiology 20 (3), 182-193 Read more

Parekh et al. (2010). Longitudinal associations of blood markers of insulin and glucose metabolism and cancer mortality in the third National Health and Nutrition Examination Survey. Cancer Causes and Control 21 (4), 631-642 Read more

Barth et al. (2010). Expression of Neuropeptide Y, Omentin and Visfatin in Visceral and Subcutaneous Adipose Tissues in Humans: Relation to Endocrine and Clinical Parameters. Obes Facts 3 (4), 245-251 Read more

Garcia et al (2010). Synthesis, characterization and biological evaluation of In(III) complexes anchored by DOTA-like chelators bearing a quinazoline moiety. Metallomics 2, 571-580 Read more

Meyer et al. (2010). Synthesis and analysis of 2-[211At]-L-phenylalanine and 4-[211At]-L-phenylalanine and their uptake in human glioma cell cultures in-vitro. Applied Radiation and Isotopes 68 (6), 1060-1065 Read more

Wolf et al (2010). Peroxiredoxin III protects pancreatic β cells from apoptosis. J Endocrinol 207, 163-175 Read more

Branschädel et al. (2010). Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: Conformational stabilization of CRD2 and control of receptor responsiveness. Cellular Signalling 22 (3), 404-414 Read more

Further Applications

Infectious diseases, e.g. Hepatitis  -  Cytotoxicity based on 51Cr release  -  Kidney clearance with 99Tc - Receptor binding  -  Iron metabolism with 59Fe  -  RIA and IRMA type immuno assays mainly with 125I  -  Thyroid hormones, e.g. T3, T4, TSH  -  Reproductive hormones, e.g. LH, Estriol, FSH, Progesterone, Testosterone  -  Drug abuse screening, e.g. THC, Cocaine, Amphetamine  -  Allergy, e.g. Histamines, IgE  -  Vitamins, e.g. Vitamin D  -  Growth deficiency, e.g. hGH  -  Neurotransmitter, e.g. Serotonin, Dopamine  -  Bone and mineral metabolism, e.g. Osteocalcin, Calcitonin  -  Gastric diseases, e.g. Gastrin, Leptin, Ghrelin - Veterinary, e.g. Canine T3, Canine TSH, Porcine GH  -  Tumour markers, e.g. AFP, CEA, PSA  -  Neonatal screening, e.g. neonatal TSH, neonatal T4  -  Diabetes, e.g. Insulin, Glucagon, C-Peptide  -  Nephrology, e.g. urinary Albumin  -  Iron metabolism, e.g. Ferritin  -  Calcium metabolism, e.g. Parathormone  -  Heart diseases, e.g. Digoxin

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Multi Crystal Gamma Counter LB 2111 Rev. 02 Nov. 2013 en PDF 6.6 MB