HERM LB 500 High Activity Radio Monitor

The Flow Monitor for High Activities

The HERM is a dedicated radio flow monitor for detecting gamma isotopes present in high activities e.g. in nuclear medicine or PET laboratories.

The sodium iodide crystal combined with a thick lead shielding provides a sensitive, reliable and stable measurement system. The Twin-Cell-Changer offers enough flexibility in terms of changing activities and flow rates for the flow through analysis.



Choice of operation

HERM can be used as a stand-alone system pre-configured via a terminal software or in a fully PC-controlled manner via the RadioStar software.

Similarly the signals detected in the HERM can be transferred an analogue channel (0 to 1 V) or via the digital USB connection


Each of the detection cells can be configured to the needs, i.e. activities and/or flow rates present in the analysis. A mechanism enabling immediate change between the two cells gives even more freedom in customization.

Downstream Control

Threshold values can be set in order to be able to control downstream devices like separation valves and fraction collectors even in a time-delayed way.


A built-in oscillator serves as a reference source for auto-control and GLP validation of the system.




Detection DeviceNaI crystal coupled to low noise photon counting PMT
Isotopesgamma and PET emitters
Digital InterfaceMini USB
Analog OutputTTL
0 to 1 V (10 Hz sampling rate)
2 programmable relay switches
DimensionsElectronics: 210 x 60 x 120 mm (w x h x d)
Detector incl. shielding: 150 x 350 x 180 mm (w x h x d)
WeightElectronics: 1 kg
Detector incl. shielding: 26 kg




Besides controlling the detector the PC software offers sophisticated functions for radiochromatographic data evaluation

  • recording of max. 4 channels incl. 2 non-isotpic ones
  • integration of peaks
  • half-life correction
  • quench-correction
  • report generation
  • export functionality, e.g. ANDI format

The software is 21 CFR part 11 compliant.


The PC software arranges the data properly in an easy-to-comprehend layout and transfers the data to spreadsheet softwares like EXCEL.


HERM flow monitor can be used in the development, production and especially quality control of Radio-Pharmaceuticals, PET istope labelled tracer substances and Radio isotope labelled substances:


Aufort et al. (2011). Synthesis, in vitro screening and in vivo evaluation of cyclic RGD analogs cyclized through oxorhenium and oxotechnetium coordination. European Journal of Medical Chemistry 46 (5), 1779-1788 Read more


Aufort  et al. (2011). Oxorhenium-Mediated Assembly of Noncyclic Selective Integrin Antagonists: A Combinatorial Approach. ChemBioChem 12 (4), 583-592 Read more


Knott et al. (2011). Simplified and automatic one-pot synthesis of 16α-[18F]fluoroestradiol without high-performance liquid chromatography purification.  J Label Compd Radiopharm, 54: 749–753 Read more


Van Dorpe et al. (2011). Desirability function combining metabolic stability and functionality of peptides. J. Peptide Sci. 17 (5), 398-404 Read more


Van Dorpe (2010). Analytical characterization and comparison of the blood–brain barrier permeability of eight opioid peptides. Peptides 31 (7), 1390-1399 Read more


Alshoukr et al. (2009). Novel Neurotensin Analogues for Radioisotope Targeting to Neurotensin Receptor-Positive Tumors. Bioconjugate Chem 20 (8), 1602–1610 Read More


Aufort et al. (2009). Synthesis and biochemical evaluation of a cyclic RGD oxorhenium complex as new ligand of αVβ3 integrin. European Journal of Medicinal Chemistry 44 (9), 3394-3401 Read More


Vergote et al. (2006). Analysis of iodinated peptides by LC-DAD/ESI ion trap mass spectrometry. Journal of Chromatography B 850  (1-2), 213-220 Read More

Format Size
Bioanalytic Instruments - Product Portfolio Brief overview scope of supply Bioanalytic (June 2014) de, en PDF 693.31 KB
HERM LB 500 HPLC detector brochure Revision 00 12/2016 de, en PDF 1.02 MB
Order Information Consumables & QC Test Devices Version Jan. 2017 de, en PDF 153.63 KB
Press & Media
Format Size
2014-03 (NL March 2014) LB 500 HERM High Energy Radio Monitor HPLC HERM & various LB 124 Contamination Monitors - Berthold Technologies Newsletter March 2014 de, en PDF 118.61 KB
2014-05 (May 2014) FlowStar LB 513 & Radio HPLC Detectors Recent applications FlowStar LB 513 & Radio HPLC Detectors - Berthold Technologies Newsletter May 2014 en PDF 133.71 KB
2014-06 (June 2014) HPLC fLumo & Monitoring LB 500 fLumo Luminescence & PET detector & Radiation Protection Equipment - Berthold Technologies Newsletter June 2014 de, en PDF 133.68 KB